Chemotherapy + durvalumab exhibited promising clinical activity in patients with mesothelioma, with additional analyses providing insights into genomic & immunologic features associated with response. Work led by AACR23 speakers FordePatrick & ValsamoA
Aspartate aminotransferase/alanine aminotransferas ≤2.5× ULN
Patients must not have participated in another clinical study with an investigational product during the last 4 weeks.No previous treatment with a PD1 or PD-L1 inhibitor, including durvalumab or any other agent targeting immune checkpoints Patients must not have a mean QT interval corrected for heart rate ≥470 ms calculated from three electrocardiograms using Frediricia’s correction.
No uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, cardiac arrhythmia, active peptic ulcer disease or gastritis and active bleeding diatheses, as well as any patient known to have psychiatric illness/social situations that would limit compliance with study requirements or compromise the ability of the patient to give written informed consent.
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