Nature research paper: TnpB structure reveals minimal functional core of Cas12 nuclease family
T.K. and V.S. are co-inventors on a patent application filed by Vilnius University. V.S. is a Chairman of and has financial interest in CasZyme. G.M. is a shareholder and a member of Ensoma SAB. The remaining authors declare no competing interests.thanks Yong-Sam Kim, Dipa Sashital and the other, anonymous, reviewer for their contribution to the peer review of this work.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
, EMSA analysis of TnpB binding to the product-like partially single-stranded , substrate-like double-stranded and nonspecific double-stranded DNA oligoduplexes., Design of the head-to-head dual-end DNA oligoduplex that was used for structural analysis of TnpB-reRNA-DNA ternary complexes., EMSA analysis of TnpB binding to the dual-end DNA oligoduplex. Positions of complexes with one and two TnpB RNPs bound are indicated., Interpretation of cryo-EM data obtained with the dual-end DNA.
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