Study Suggests Mind-Body Benefits of GLP-1s

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Study Suggests Mind-Body Benefits of GLP-1s
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Med record data shows improvements in anxiety and depression in people taking the drugs for either diabetes or obesity.

People taking a popular type of drug for weight loss or to manage diabetes have a lower likelihood of being newly diagnosed with depression or anxiety, according to an analysis of millions of people's health records.were published this week by researchers from the electronic health record company Epic.

A reduced likelihood of being diagnosed with anxiety was also observed among people with diabetes after they started taking a GLP-1 agonist, compared to people with diabetes who didn't take one of the drugs. Again, tirzepatide showed the greatest reduction in odds, with people taking that drug experiencing a 60% reduced likelihood of being newly diagnosed with anxiety.

This latest analysis included the drugs dulaglutide, exenatide, liraglutide, semaglutide, and tirzepatide. The medicines, used for weight loss or to manage diabetes, include the brand names Byetta, Ozempic, Mounjaro, Trulicity, Wegovy, and Zepbound. The researchers also looked for links between depression or anxiety diagnoses among people taking liraglutide , but found that there was little to no change in the likelihood of being diagnosed with depression or anxiety after starting liraglutide.

This latest analysis from Epic Research only looked at health records, was not published in a peer-reviewed journal, nor could it establish a definitive role the medications may have played in whether or not someone was diagnosed with depression or anxiety. It's unknown whether people in the study had symptoms of depression or anxiety before starting the medications.

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