Nature research paper: Oligomerization-mediated activation of a short prokaryotic Argonaute
While eukaryotic Argonautes and long prokaryotic Argonautes cleave nucleic acids, some short pAgos lack nuclease activity and hydrolyze NAD. We present a hierarchical activation pathway for
progresses through distinct oligomeric forms, including a monomeric apo state, a monomeric RNA/DNA-bound state, two dimeric RNA/DNA-bound states, and a tetrameric RNA/DNA-bound active state. These snapshots together identify oligomerization as a mechanistic principle of is inactive, its RNA/DNA-binding channel occupied an auto-inhibitory motif in TIR-APAZ. Upon RNA/DNA binding,
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