In Brief: Servier's successful phase 3 trial of vorasidenib in patients with a slow but usually fatal form of brain cancer, the first clinical breakthrough in the field for two decades, is likely to become a new standard of care
Servier’s successful phase 3 trial of vorasidenib in patients with a slow-growing but usually fatal form of brain cancer demonstrates the power of good brain penetrance.
The oral therapy vorasidenib inhibits both isocitrate dehydrogenases in their mutated forms, which disrupt cellular metabolism and drive oncogenesis in grade 2 in post-operative patients with recurrent or residual IDH-mutated low-grade gliomas: those on the drug had a median PFS of 27.7 months, compared with 11.1 months for those on placebo. The drug, the first clinical breakthrough in the field for two decades, is likely to become a new standard of care.
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