Octopuses and squid are masters of RNA editing while leaving DNA intact

Indonesia Berita Berita

Octopuses and squid are masters of RNA editing while leaving DNA intact
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Opening cages, using tools. Here’s yet another reason to love octopuses.

. Since then, the researchers have examined multiple species of octopus, squid and cuttlefish, each time finding tens of thousands of recoding sites.

Having a wide selection of proteins may give cephalopods “more flexibility in responding to the environment,” Albertin says, “or give you a variety of solutions to the problem in front of you.” In the nervous system, RNA editing might contribute to flexibility in thinking, which could help explain why octopuses can unlock cages or use tools, some researchers think.

In longfin squid, the mRNA that produces kinesin-1 has 14 recoding sites, Rangan has found. She examined mRNAs from the optic lobe — the part of the brain that processes visual information — and from the stellate ganglion, a collection of nerves involved in generating the muscle contractions that produce jets of water to propel the squid., Rangan and Samara Reck-Peterson, also of UC San Diego, reported last September in a preprint posted online at bioRxiv.org.

If it’s not all that helpful, why have cephalopods persisted with RNA recoding for hundreds of millions of years? RNA editing may stick around not because it is adaptive, but because it is addictive, Zhang says. RNA editing may work as a transition phase, letting organisms try out a switch from adenine to guanine without making a permanent change in their DNA. Over the course of evolution, sites where adenines are recoded in RNA in one cephalopod species are more likely than unedited adenines to be. And for heavily edited sites, evolution across cephalopods seems to favor a transition from A to G in DNA . That favors the idea that editing can be adaptive.

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