A meta-analysis shows that dietary salt substitutes not only lower blood pressure but also have a clear impact on hard clinical endpoints, lowering the risk of MI, stroke, and death from all causes of CVD. MedTwitter
But SSaSS was conducted in China, and it was unclear whether these benefits would apply to people in other parts of the world.
A meta-analysis of blood pressure data from 19 trials that included 29,528 participants showed that salt substitutes lowered systolic blood pressure by 4.61 mm Hg and diastolic blood pressure by 1.61 mm Hg . Each 10% lower proportion of sodium chloride in the salt substitute was associated with a 1.53 mm Hg greater reduction in SBP and a 0.95 mm Hg greater reduction in DBP.
Tian and colleagues say,"Broader population use of salt substitute is supported by the absence of any detectable adverse effect of salt substitutes onThey note, however, that all of the trials took"pragmatic steps to exclude participants at elevated risk of hyperkalemia, seeking to exclude those withOffering perspective on the study, Harlan Krumholz, MD, with Yale New Haven Hospital and Yale School of Medicine, New Haven, Connecticut, said it provides"useful information by...
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