Pregnancy is essential to the future of humanity, and it’s way too mysterious.
Stephanie Hinze holds her son Harrison, 2, at home in Gainesville, Ga. Hinze, who suffers from spina bifida, is five months pregnant with her third child. By Carolyn Y. Johnson Carolyn Y. Johnson Science reporter Email Bio Follow March 6 at 9:00 AM For two years, a group of world-class scientists pitched their idea for a hot new biotech company to investors: a start-up focused on a promising therapy for preeclampsia, a serious pregnancy complication that can become life-threatening.
“We all joke about pregnancy brain, but I was still able to make decisions for myself and my fetus,” said Sonja Rasmussen, a pediatrician and clinical geneticist at the University of Florida. Some researchers note that pregnant women are increasingly being studied in their own right — and not just as the environment in which a fetus develops. Recent evidence suggests that pregnancy complications may predict women’s susceptibility to dementia or heart disease decades later.
“If you want to exclude a pregnant woman from research, all you’ve got to do is check the box; she’s excluded, no explanation needed,” Lyerly said. “If you want to include her, there’s a whole slew of paperwork and decisions, and you have to justify your decision.” “It’s one of the things I’m proudest of in my career is we looked at that and weighed the risk and benefits instead of the knee-jerk, ‘We can’t let pregnant women have that because the data are limited,’ ” Rasmussen said.
Hinze, who has two sons, one of whom is adopted, is now pregnant for the second time. She says she was lucky — her first pregnancy went smoothly and her medical team was supportive, contrasting with anecdotes she has heard from others. But at each step, they were solving new puzzles. The basic science of pregnancy, too, is getting a closer look, as NIH has so far funded $76 million in research projects to study the human placenta, the temporary organ that provides oxygen and nutrients to the fetus. The recent discovery that it is possible to grow a miniature version of the placenta in a laboratory setting may help scientists understand fundamental questions about how it develops, in part in response to secretions from the uterus.
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