Data suggest that AEF0117 weakens the effects of cannabis and decreases a person's desire to use it without causing withdrawal symptoms.
"It then took 2 years to create a synthetic molecule that could mimic the effects of pregnenolone on the CB1 receptors," Piazza continued. Unlike pregnenolone, the new molecule needed to to be fully absorbable, stable, and not transformable into other steroids.AEF0117 was assessed as part of a placebo-controlled, double-blind, phase 2a study. The participants were volunteers who had a cannabis addiction. In the treated group, the volunteers received either 0.
"I call this triple action: reduced positive effects of cannabis, reduced desire to use it, and a lack of withdrawal symptoms linked to the partial receptor inhibition," said Piazza. Commenting on the study for Medscape, Guillaume Davido, MD, a psychiatrist who specializes in addiction studies at Bichat Hospital in Paris, said,"Patients really miss the psychoactive anxiolytic effect of cannabis when they stop using it. This is what makes stopping so difficult. Getting rid of this 'honeymoon' effect with the product is a considerable step forward." Davido is sure AEF0117 will be approved for prescription use.
Currently, no treatments are approved for cannabis use disorder, said Davido."At the moment, we can only provide medicinal products to treat cannabis withdrawal symptoms, such as irritability, sleep disorders, and anxiety."A phase 2b trial has been launched in the United States. It is in the process of recruiting 330 participants with cannabis addiction at 11 sites. Recruitment is scheduled to be completed by October.
The results should be available by mid-2024."And if its therapeutic efficacy is confirmed, a whole new pharmacology of receptors is opened up to us," said Piazza.This article was translated from the
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