A study of vaccinated parents & unvaccinated kids estimated having a single parent vaccinated w/ the Pfizer-BioNTech vaccine associated w/ as much as 26.0% decreased risk of infection for children; with 2 vaccinated parents, risk decreased as much as 71.7%
The secondary attack rate from an infected parent to susceptible children in the household by parent vaccination status. The unit of observation for this analysis consisted of households in which a parent was infected with SARS-CoV-2. The exposure was the vaccination status of the index parent. The outcome was infection of at least one child in the household at days 3-8 following diagnosis of the index parent.
shows a schematic representation of the mechanism by which the direct protection of the parent and the reduction in the secondary attack rate comprise the indirect protection observed for the children.An illustration showing the indirect effect of parental vaccination on children’s risk of SARS-CoV-2 infection, and two of its composite parts: The direct effect of vaccination on the parents and the risk of transmission from an infected parent to his or her children .
In the sensitivity analysis using bacterial diarrhea as a negative control outcome, the association was -14% for one vaccinated parent and -16% for two vaccinated parents . In this study, we estimated the indirect protective effect of vaccinating parents with the BNT162B2 mRNA COVID-19 vaccine on their children’s risk of SARS-CoV-2 infection in households without prior infection. This estimation was performed both for the primary vaccine series during a period in which Alpha variant was dominant and for the vaccine booster dose during a period in which the Delta variant was dominant.
Previous findings have also shown a substantial indirect effect for SARS-CoV-2 vaccines. A study focusing on unvaccinated spouses of healthcare workers found the indirect effect to be 43% ten weeks after receipt of the first vaccine dose (
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