A fourth dose of existing mRNA COVID-19 vaccines may have only 'marginal benefits' for younger, healthy adults, according to a new Israeli study published Wednesday in the New England Journal of Medicine.
The research assessed 270 health care workers at the Sheba Medical Center in Tel Aviv who received a second booster shot of either the Pfizer or Moderna vaccines, four months after initially getting three Pfizer shots. FILE PHOTO
Each was age-matched against two participants in a control group that had received only three doses of Pfizer, with the median ages in the groups ranging from mid-fifties to early sixties. Those who got a fourth shot of Pfizer were 30 percent less likely to acquire infection than those who got three doses, while those who got Moderna were 18 percent less likely to get infected.
The study authors, led by Gili Regev-Yochay, wrote that their research seems to indicate the advantages of three doses of vaccine designed against the original strain of coronavirus had hit a ceiling in terms of immune response, with additional boosters only restoring waned immunity, rather than taking it to new heights.
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