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So Copenhagen University psychologist Vibeke Dam and colleagues took a closer look at the drug's impacts on 90 patients with moderate to severe depression using brain scans and cognitive and mood assessments before and after taking SSRIs for eight weeks.
Following the treatment period, patients had almost a 10 percent reduction in the cell receptors that the SSRI bind to compared to how many were detected before they were put on the medication. The patients also showed improvements in the memory cognitive tests, particularly in their ability to recall words.
While the patients showed some improvement in their depression, the fact any mood changes didn't scale with the changes in the 5HT4 receptors raised doubt over whether this mechanism is responsible for SSRIs' clinical effects.. Besides, we also can't know for sure they're not working in a way researchers have just yet to figure out.
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