More women than men are diagnosed with Alzheimer’s—the most common form of the neurodegenerative condition dementia—but scientists aren’t sure why.
Hormone replacement therapy used to ease the symptoms of menopause has been linked to a slight increased risk of Alzheimer’s disease, according to the authors of a study that stands in contrast with past research indicating the drugs could prevent the condition.
Past studies have suggested the regimes could help to prevent Alzheimer's disease. One 1996 study published in The Lancet cited by the authors involved 1,124 elderly women, and indicated estrogen could boost brain neurons, and slow the build-up of amyloid proteins linked to Alzheimer's.
They compared 84,739 postemenopausal women in Finland who were diagnosed with Alzheimer’s disease during this period, with the same number of postmenopausal women without the condition who acted as the control group. The hormone replacement therapies the women used were noted. The authors of the study published in the journal The BMJ wrote in their conclusion: “Long term use of systemic hormone therapy might be accompanied with an overall increased risk of Alzheimer’s disease, which is not related to the type of progestogen or the age at initiation of systemic hormone therapy.
However, the pair added: “Concerns about longer-term use of estrogen plus progestin on cognitive outcomes remain.” “Studies that look for patterns in medical records can be extremely useful for identifying factors linked with Alzheimer’s risk, but they can’t tell us the root cause of that link.
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