Nature research paper: Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity
. Here we show that Omicron spike has higher affinity for ACE2 compared to Delta as well as a marked change of antigenicity conferring significant evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutralising antibodies after two doses. mRNA vaccination as a third vaccine dose rescues and broadens neutralisation. Importantly, antiviral drugs remdesivir and molnupiravir retain efficacy against Omicron BA.1.
Izumi Kimura, Daichi Yamasoba, Jumpei Ito, Keiya Uriu, Yusuke Kosugi, Mai Suganami, Akiko Oide, Miyabishara Yokoyama, Mika Chiba & Kei SatoSaman Fatihi, Surabhi Rathore, Terumasa Ikeda, Chihiro Motozono, Hesham Nasser, Ryo Shimizu, Yue Yuan, Kazuko Kitazato & Haruyo HasebeSamantha K. Zepeda, John E. Bowen, Anshu Joshi, Alexandra C.
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