Nature - Vaccines Elicit Highly Conserved Cellular Immunity to SARS-CoV-2 Omicron
The highly mutated SARS-CoV-2 Omicron variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 Spike. Cellular immune responses, particularly CD8+ T cell responses, likely contribute to protection against severe SARS-CoV-2 disease. Here we show that cellular immunity induced by current SARS-CoV-2 vaccines is highly conserved to the SARS-CoV-2 Omicron Spike. Individuals who received Ad26.COV2.
S or BNT162b2 vaccines demonstrated durable Spike-specific CD8+ and CD4+ T cell responses, which showed extensive cross-reactivity against both the Delta and Omicron variants, including in central and effector memory cellular subpopulations. Median Omicron Spike-specific CD8+ T cell responses were 82-84% of WA1/2020 Spike-specific CD8+ T cell responses.
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