In Dr. Siddhartha Mukherjee's new book, 'The Song of the Cell,' he writes about the emerging field of cell therapy and about how cellular science could one day lead to breakthroughs in the treatment of cancer, HIV, Type 1 diabetes and sickle cell anemia.
Mukherjee has a particular interest in T cells — a type of white blood cell and part of the immune system activated to fight disease. He's been treating patients in India who have certain types of cancer with genetically engineered T-cell variants, and the results have been striking:"One day the cancer's there. The next day the cancer is virtually gone, eaten up by these T cells," he says.
"It's hard for me to convey the excitement that's sweeping through the whole field of cell biology ... the kind of headiness, giddiness, the madness, the psychic power that grips you once you get into the field," Mukherjee says.[The treatment] we extract the T cells from the from a patient's body. And then we use a gene therapy to basically weaponize them, to activate them and weaponize them against the cancer. We grow the T-cells in flasks in a very, very sterile chamber.
In Emily's case, she was about 7, I think, when she was first treated. She had a complete response. She also had a very terrifying course. When the T cells get activated, they release an incredibly inflammatory cascade, sort of like, as I say in the book, it's sort of like soldiers on a rampage. And you can get so much of a rampage of T cells killing cancer that body goes berserk, it can't handle this kind of attack.
cell or make antibodies against that flag, that molecule, that protein that's on the cell surface ... and drive the immune system to reject that cell type.I could sense the sense of doom and also the sense of uncertainty. Uncertainty itself causes anxiety, which is actually one of the most prominent symptoms of depression.
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A cell biologist shares the wonder of researching life's most fundamental formPhysician Siddhartha Mukherjee explains how cellular science could lead to breakthroughs in the treatment of cancer, HIV, Type 1 diabetes and sickle cell anemia. His new book is The Song of the Cell.
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