These new COVID mutations might not make the virus more infectious the way spike mutations do, but they could be associated with longer infections.
When the pharmaceutical industry scrambled to develop the first
It’s possible the virus is accumulating non-spike mutations in an attempt to gain some advantage over our collective immunity as the That’s one reason why the vaccines have been getting somewhat less effective, and we’re seeing more and more breakthrough cases in vaccinated people. And it should come as no surprise that one of the leading contenders for the next dominant subvariant,, features a particularly worrying mutation on the spike called R346T.
For now, it seems the spike and non-spike mutations are working together. The spike mutations make the virus steadily more contagious. “Mutations in [the] spike have been identified in every major variant that then out-competes the previous variant,” Frieman explained. Frieman said his goal is to scrutinize these non-spike mutations in order to “figure out what they do, how they do it [and] why they make the virus better at being a virus.” “Then we can use that information to make drugs,” including new antiviral therapies and vaccine formulations.
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