It’s like Google Maps, but for mouse bodies.
To make the mice glow, Ertürk and colleagues pumped cholesterol-removing chemicals along with antibodies tagged with fluorescent molecular markers into the dead animals via the heart and blood vessels, a proven tactic that allows liquids to traverse the entire body. Then the team made all the tissues transparent, and the mice were ready for their close-ups.
One of the resulting maps depicts a comprehensive view of the network of nerves that runs beneath the skin and around organs. Another shows off the lymphatic system, an open network of organs and lymphatic vessels that helps fight off pathogens and transport cellular waste for removal.
And in mice with cancer, the team documented clumps of immune cells inside and near the tumors. The role that these clusters play in controlling cancer is unclear, Ertürk says. But wildDISCO offers scientists a way to investigate. wildDISCO might also help with studies that focus on animals other than mice, says Yijun Su, an imaging specialist at Howard Hughes Medical Institute’s Janelia Research Campus in Ashburn, Va., who was not involved in the work. Scientists working with fruit flies, frogs or zebra fish might use a similar “recipe,” he says, to take clearer snapshots of their anatomy.
Immune cells cluster inside and near a mouse’s cancer tumors . How the cells might affect cancer progression is unclear, but wildDISCO could help researchers investigate.
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