A study in Neurology reveals an association between sleep apnea, reduced deep sleep, and brain biomarkers linked to stroke, Alzheimer's disease, and cognitive decline. The research does not establish causation, but highlights the need for further investigation into sleep quality improvement and slee
A recent study suggests that individuals with sleep apnea who spend less time in deep sleep may be more likely to exhibit brain biomarkers associated with an increased risk of stroke, Alzheimer’s disease, and cognitive decline. Involving 140 participants with obstructive sleep apnea, the study found that a decrease in slow-wave sleep was linked to increased white matter hyperintensities and reduced axonal integrity, both indicative of early cerebrovascular disease.
“These biomarkers are sensitive signs of early cerebrovascular disease,” said study author Diego Z. Carvalho, MD, MS, of the Mayo Clinic in Rochester, Minnesota, and a member of the American Academy of Neurology. “Finding that severe sleep apnea and a reduction in slow-wave sleep are associated with these biomarkers is important since there is no treatment for these changes in the brain, so we need to find ways to prevent them from happening or getting worse.
People with severe sleep apnea had a higher volume of white matter hyperintensities than those with mild or moderate sleep apnea. They also had reduced axonal integrity in the brain.
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