Treatment with JAK inhibitors does not appear to be associated with an increased risk of VTE in patients with atopic dermatitis DermTwitter
Two studies found the overall incidence rate of VTE for patients with AD was 0.23 events per 100 patient-years. The risk was did not differ from that in non-AD patients .
Another 15 studies included 8,787 participants with AD and found no significant differences in the rates of VTE in AD patients treated with JAK inhibitors versus those treated with placebo or. However “with the increasing applications of JAK inhibitors in AD, more clinical data are needed to identify patients at high risk for VTE,” noted the authors.
“We need more, long-term data,” agreed Drucker, adding that a major issue is the short-term nature of AD trials to date , which “don’t provide adequate reassurance.” He said although the FDA’s boxed warning was prompted by a trial in RA patients treated with tofacitinib , and the same risks have not been demonstrated specifically for the JAK inhibitors used for a patients with AD, he still remains cautious.
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