SPONSORED: Alzheimer's researchers at UT Health San Antonio contributed to a recent global study on gene variants found in the disease.
Twenty-one million. That’s the number of genetic variations in the human genome that researchers are sifting through to identify patterns predisposing people to Alzheimer’s disease.
Seshadri is a founding principal investigator of the International Genomics of Alzheimer’s Project, or IGAP. Biggs Institute faculty contributed data for the newest research from IGAP, published in Nature Genetics, and helped craft worldwide discussion on implications of the findings.Genomic data of half a million people were used in this latest IGAP study, including 30,000 people with confirmed Alzheimer’s disease and 47,000 people categorized as proxies.
In 2009, the year of the first genome-wide association studies, researchers knew of one gene, called APOE, associated with late-onset Alzheimer’s disease. Before journal publication on April 4, 2022, researchers had a list of 40 such genes. This new paper confirmed 33 of them in a larger population sample and added 42 new genetic variants not described before.
Older Hispanic adults are estimated to be at 1.5 times greater risk of Alzheimer’s and other dementias than non-Hispanic whites. Dementia is costing individuals, caregivers, families and the nation an estimated $321 billion in 2022, according to the Alzheimer’s Association.
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