The US Food and Drug Administration approved a highly anticipated new drug designed to slow cognitive decline in patients in the early stages of Alzheimer’s disease. | AFP
Leqembi and Aduhelm, which were both jointly developed by Japan’s Eisai and Biogen of the United States, “represent an important advancement in the ongoing fight to effectively treat Alzheimer’s disease,” the FDA said in a statement.
Leqembi is “the latest therapy to target and affect the underlying disease process of Alzheimer’s, instead of only treating the symptoms of the disease,” Dunn said. The phase three trial involved nearly 1,800 people, divided between those given the drug and given a placebo, and ran over 18 months. The results showed that 17.3 percent of patients administered the drug experienced brain bleeds, compared with nine percent of those receiving a placebo.And 12.6 percent of those taking the drug experienced brain swelling, compared with just 1.7 percent of those in the placebo group.In Alzheimer’s disease, two key proteins, tau and amyloid beta, build up into tangles and plaques, known together as aggregates, which cause brain cells to die and lead to brain shrinkage.
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