The updated COVID-19 boosters from Pfizer Inc /BioNTech SE and Moderna helped prevent symptomatic infections against the new XBB-related subvariants, offering new evidence of how the vaccines perform against these fast-spreading strains, U.S. officials said on Wednesday.
helped prevent symptomatic infections against the new XBB-related subvariants, offering new evidence of how the vaccines perform against these fast-spreading strains, U.S. officials said on Wednesday.
Released last fall, the updated boosters target the BA.4 and BA.5 Omicron variants of the SARS-CoV-2 virus, which are no longer dominant. The now-dominantLab studies had suggested that vaccine protection was lower against the XBB variants compared with prior variants, raising questions about how well the vaccines worked against these rising strains of the virus, Jackson said.
The CDC said the updated vaccine worked similarly against BA.5-related infections and XBB/XBB.1.5-related infections. It was 52% effective at preventing infections against BA.5 and 48% against XBB/XBB.1.5 among those aged 18-49. Effectiveness fell to 37% against BA.5 and 43% against XBB/XBB.1.5 among those aged 65 years and older.
Study author Ruth Link-Gelles of the CDC said overall, the vaccines cut the risk of symptomatic infection by about half on a population, but individuals see a different benefit based on their risk factors.
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