UC scientist Jennifer Doudna loses patent rights to a gene editing technique that earned a Nobel Prize.
UC Berkeley’s Jennifer Doudna earned a Nobel Prize her lab’s work on Crispr-Cas9, a revolutionary method to edit DNA.Ending — for now — a long, vitriolic and expensive fight over commercial application of a pioneering tool that is transforming biological research, a board of the U.S. Patent and Trademark Office
Vowing to challenge the decision, Doudna said that “today’s USPTO ruling is surprising and contrary to what more that 30 countries and the Nobel Prize Committee have decided regarding the invention of CRISPR-Cas9 genome engineering technology for use in all cell types, including human cells.” Doudna and Charpentier have each continued to lead the worldwide development and application of CRISPR technology. Doctors are now testing it as a cure for genetic disorders such as sickle cell disease, cancer and hereditary blindness.
Monday’s ruling throws a monkey wrench into the business model of several up-and-coming biotech companies, such as Caribou Biosciences of Berkeley and Boston’s Intellia Therapeutics and CRISPR Therapeutics, who aim to create treatments using CRISPR. UC has fought for years in its quest to control over the rights to the powerful gene-editing technology.
Feng Zhang and colleagues at the Broad Institute didn’t conceive of the idea. But in January 2013, they reported that they had used Doudna’s approach in animal cells with a nucleus, called eukaryotic cells — and that they had successfully edited mouse and human cells.
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