A new U.S. study will test whether pairing molecularly targeted drugs will work better than single drugs to wipe out cancer.
The U.S. government is launching a wide-ranging effort to study whether combining two drugs matched to molecular weak spots in a patient’s tumor will work better to wipe out the cancer than a single such drug.ComboMATCH study formally announced today
This framework “will allow us to explore many exciting novel drug combinations,” says oncologist Roisin O’Cearbhaill of Memorial Sloan Kettering Cancer Center, one of the leaders of ComboMATCH. Before that effort, a few such “targeted” drugs had been approved for specific cancers such as leukemia and breast tumors. NCI-MATCH hoped to add more by testing compounds matched not to a patient’s broad cancer type, but to their tumor’s individual genetic profile and a resulting protein target. Tumor sequencing has since become a routine part of care for many cancer patients.
That’s largely because tumors that shrink when treated with a single targeted therapy eventually start growing again, as a few preexisting or newly evolved drug-resistant cancer cells, or “clones,” expand and take over a tumor.
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