The more extended the period that the animals shared circulatory systems, the more sustained the benefits were to the older mouse. A process of surgically joining the circulatory systems of a young and old mouse has been found to slow aging at a cellular level and extend the older animal's life by
discovered the longer the animals shared circulation, the longer the anti-aging benefits lasted once the two were no longer connected.
White and colleagues set out to determine whether the benefits of heterochronic parabiosis – surgically fusing two animals of different ages to enable a shared circulatory system – were fleeting, or more long-lasting. White said the ages of the mice were also important, with the young mouse aged four months, and the older mouse aged two years.
White said the experiment was designed to study if long-term exposure to young blood will cause lasting effects in the old mouse. Pairing humans for heterochronic parabiosis is obviously not practical or even ethical, he said. He also noted that other anti-aging strategies, such as calorie restriction, work better to extend longevity in mice.
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