The debate over whether artificial sweeteners are healthy rages on, with new findings suggesting a troubling association with cardiovascular disease risk and anxiety. MedTwitter
that mice that drank water with aspartame showed pronounced anxiety-like behaviors in maze tests. This occurred at doses equal to less than 15% of the maximum daily human intake recommended by the US Food and Drug Administration. Aspartame exposure also resulted in changes to the expression of genes that affect the amygdala, a brain region that regulates anxiety and fear.
, F. Perry Wilson, MD, MSCE, notes that he is"not terribly worried right now about my monkfruit sweetener, or my sugar-free gum, or my toothpaste. While the harms from sugar substitutes are still mostly theoretical, the harms of sugar are all too real." His conclusion that erythritol may be the"lesser of two evils" is based on well-established conclusions about sugar-sweetened products that contain material like high-fructose corn syrup.
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