New research suggests some patients do better with tirofiban than with low-dose aspirin following disabling stroke without a visible large or medium intracranial vessel occlusion. ISC23
showed no beneficial effect on stroke outcomes. Zi and colleagues investigated the possibility that tirofiban would be effective for a more select group of patientsThe double-blind RESCUE-BT2 trial included 1177 adult patients across China with acute ischemic stroke without large or medium size occlusion determined by imaging, and a National Institutes of Health Stroke Scale score of 5 or greater.
Researchers randomly assigned patients to one of two groups: the tirofiban group or the aspirin group. The tirofiban group received an initial infusion of 0.4 μg/kg/minute for 30 minutes followed by a continuous infusion of 0.1 μg/kg/minute for up to 48 hours, plus oral placebo; the aspirin group received IV placebo and oral low-dose aspirin.
Only 0.99% of the tirofiban group and none in the aspirin group had a symptomatic intracranial hemorrhage within 48 hours , which was another secondary outcome"The rates of intracranial hemorrhage were low but slightly higher with tirofiban," noted ZiA limitation of the study was that it included only Asian patients."Caution is warranted in generalizing the results to other populations," said ZiAsked to comment, Tudor G.
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