BQ.1.1 is very contagious. But that’s not the subvariant’s most alarming quality. What’s most worrying is that it also evades certain antibodies.
finally subsided in late July, new subvariants were already competing for dominance—and the opportunity to drive the nextA little over two months later, epidemiologists are close to naming a winner. In the United Kingdom, infections from a highly mutated subvariant called BQ.1.1
Highly contagious and immune-evasive, BQ.1.1 is poised to take advantage of an increasingly vulnerable global population asa fresh wave of infections is coming. It’s exactly when. But antibody therapies have proved popular and effective against other variants and subvariants of SARS-CoV-2. BQ.1.1 could begin to render them obsolete, narrowing our options for preventing COVID infectionsOne of the most important trends, as the COVID pandemic grinds toward its fourth year, has been the “decoupling” of the infection rate from the death rate.But by then tens of millions of people were vaccinated—and hundreds of millions more had natural antibodies from past infection.
Fortunately, the latest mRNA boosters from Moderna and Pfizer are still highly effective against BQ.1.1. There’s a good reason for this. Moderna and Pfizer formulated the new bivalent boosters specifically to provide immunity against BA.5. BQ.1.1 is a form of BA.5, albeit with additional mutations. The numbers aren’t much better in other developed countries—and far worse in developing countries. And that means the world is mostly depending on antibodies from past infection to prevent a catastrophic wave of new cases and deaths.
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