Joanie Knight has a message for anyone considering drugs like Ozempic or Wegovy. “I wish I never touched it. I wish I’d never heard of it in my life.”
Joanie Knight has a message for anyone considering drugs like Ozempic or Wegovy, which have become popular for the dramatic weight loss they can help people achieve.
Emily Wright, 38, a teacher in Toronto, Canada, started taking Ozempic in 2018. Over a year, she said she lost 80 pounds, which she’s been able to keep off. But Wright said she now vomits so frequently she had to take a leave of absence from her job.The diabetes drug Ozempic, and its sister drug for weight loss, Wegovy, utilize the same medication, semaglutide.
So far, extreme and unrelenting cases like these are believed to be rare, and they may be a result of the drug unmasking or worsening a pre-existing “slow stomach.” Doctors say people can have a silent condition called delayed gastric emptying and not know it. There’s nothing on the drugs’ labels that specifically cautions that gastroparesis may occur.
On the other hand, this is how the drugs work, although not many doctors or patients understand this or the problems that may follow, Camilleri said.how one of the first GLP-1 agonists, a drug called liraglutide, affects stomach function. Fortunately, people in the study seemed to adjust to the medication over time. After 16 weeks, people in the group taking liraglutide were clearing about half the food they ate from their stomachs in about 30 minutes, as opposed to seven minutes in the placebo group. Symptoms of nausea and vomiting seemed to ease, too.
A gastric emptying study — a test that measures how food moves through the stomach — put Knight in the severe category. She said she stayed nauseous all the time, no matter how little she ate, and took a prescription anti-nausea medication “like it was candy.”prescription information In September 2020, Wright had to be hospitalized for dehydration related to the vomiting, and that prompted her to push her doctors for more answers. A gastric-emptying study showed she had gastroparesis. Her doctors put her on two more medications to try to help her manage her symptoms but didn’t take her off the Ozempic because they didn’t suspect it was contributing.
Then instead of just vomiting the food she’d recently eaten, Wright noticed she was throwing up food she’d eaten three or four days prior.“Then the GI doctor said, ‘Well, I’ve been seeing a lot of clients coming in with full stomachs on endoscopy who are on Ozempic. So let’s try taking you off the Ozempic,’ ” Wright said.
Knight, the Louisiana mom, eventually had stomach bypass surgery. It’s similar to the technique used for weight loss, but it can also be a treatment for severe cases of gastroparesis. She said it has allowed her to eat some of her favorite foods again, like a few bites of pizza or chicken. The FDA said it has been unable to determine if the medications were the cause or if the gastroparesis may have been caused by a different issue.
The FDA said patients with gastroparesis weren’t excluded from clinical trials of these medications, and the benefits for diabetes and weight management “may outweigh the risks in some patients with gastroparesis or delayed gastric emptying.”
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