They also have implications for nausea-free chemotherapy treatment.
A new class of compounds could provide the benefits of gastric bypass surgery without going under the knife or nausea, according to new research presented at the spring meeting of theBut weight loss isn't the only benefit of the potential treatments. According to the researchers, their approach has proven to reduce blood sugar levels as well as opioid cravings. It could also have implications for creating nausea-free chemotherapy drugs.
These advantages are connected to a change in the gut's release of particular hormones, such as glucagon-like peptide-1 and peptide YY . They indicate fullness, suppress hunger, and stabilizeDoyle's team developed a peptide that stimulates two PYY receptors and the GLP-1 receptor. This substance, known as GEP44, made obese rats consume up to 80 percent less food than usual.
The mammals lost an average of 12 percent of their body weight during one 16-day study. That's more than three times the amount lost by rats given liraglutide - an injection solely activates the GLP-1 receptor permitted to treat obesity by the U.S. Food and Drug Administration.According to the team's most recent findings, GEP44-induced weight loss can also be linked to higher energy expenditure, manifesting as increased activity, heart rate, or body temperature.
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