Read our latest Review: PrecisionMedicine for rheumatology may be in its infancy, but the field is gaining momentum. Judith James and colleagues OMRF outline the progress, promises and the challenges of translating recent advances into the clinic.
Systemic autoimmune rheumatic diseases exhibit extensive heterogeneity in clinical presentation, disease course, and treatment response. Therefore, precision medicine — whereby treatment is tailored according to the underlying pathogenic mechanisms of an individual patient at a specific time — represents the ‘holy grail’ in SARD clinical care. Current strategies include treat-to-target therapies and autoantibody testing for patient stratification; however, these are far from optimal.
Recent innovations in high-throughput ‘omic’ technologies are now enabling comprehensive profiling at multiple levels, helping to identify subgroups of patients who may taper off potentially toxic medications or better respond to current molecular targeted therapies. Such advances may help to optimize outcomes and identify new pathways for treatment, but there are many challenges along the path towards clinical translation.
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