In a phase 2 randomized clinical trial in patients with severe hypertriglyceridemia, pegozafermin, a long-acting analog of human FGF21, was safe and met the primary endpoint of the trial for reducing serum triglyceride levels DLBHATTMD IcahnMountSinai
, LS mean percent change from baseline to week 8 in liver fat fraction assessed by MRI-PDFF., MRI-PDFF images depicting changes in liver fat fraction from representative participants with elevated baseline liver fat fraction defined as >25%., Proportion of participants who achieved liver fat normalization , ≥30% or ≥50% relative reduction in liver fat after 8 weeks.
Eligibility criteria allowed for the enrollment of participants on stabilized regimens of approved lipid-modifying therapies , such as statins, prescription fish oil and/or fibrates. Approximately 55% of participants enrolled were on background LMT, with a majority on a statin ), followed by prescription fish oil and fibrates .
, but the study was ultimately amended to include a fibrate cohort, with the additional criteria that those participants must have had at least 6% liver fat at baseline. Enrollment into this arm proved difficult and, therefore, participants on fibrates were likely underrepresented in the final study population relative to clinical practice.
. More recently, data from the Rochester Epidemiology Project showed that only 46% of patients with primary isolated hypertriglyceridemia ) have not demonstrated an add-on reduction in CV events in patients on statin therapy . For instance, while the REDUCE-IT trial did find a 25% reduction in a composite of CV events in high-risk patients, only part of the benefit was predicted by TG lowering, suggesting the outcomes were attributable to broader pleiotropic effects of IPE
Indonesia Berita Terbaru, Indonesia Berita utama
Similar News:Anda juga dapat membaca berita serupa dengan ini yang kami kumpulkan dari sumber berita lain.
BMI measurement deemed ‘racist’ in new medical report: ‘This is politics, not medicine'In a new report, the American Medical Association (AMA) calls for abolishing the body mass index (BMI) as a means of assessing body fat. Dr. Marc Siegel weighed in with reaction.
Baca lebih lajut »
Penn Medicine stops submitting data to U.S. News ‘best hospital’ rankingsThe move takes effect in 2024, as Penn already submitted data for new rankings that come out this summer.
Baca lebih lajut »
Leveraging the structures of the COVID-19 pandemic response for successful control of Ebola in Uganda - Nature MedicineLeveraging the structures of the COVID-19 pandemic response for successful control of Ebola in Uganda. Correspondence from Hskyobe and colleagues MinofHealthUG
Baca lebih lajut »
Why did people start eating Egyptian mummies?Mummies were a prescribed medicine in Europe for 500 years.
Baca lebih lajut »
Austin Killips says trans athletes are ‘statistically underrepresented’ despite ‘nature of the discourse'Transgender female cyclist Austin Killips addressed the national debate surrounding trans athletes' participation in sports, adding that they are “statistically underrepresented.'
Baca lebih lajut »
Opinion: What The OceanGate Incident Taught Us About Human NatureBillionaires, hubris and inappropriate jokes — maybe there is a lesson in the tragic loss.
Baca lebih lajut »