Study finds brain signals in people with severe depression flow in the wrong direction

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Study finds brain signals in people with severe depression flow in the wrong direction
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The anterior cingulate cortex and the anterior insula were the two identified brain regions that showcased abnormal signal flow.

In this study, this therapy has shown promise in modifying brain activity in patients suffering from major depression.

The researchers tested SNT on study participants; 23 received the therapy, and 10 received a placebo treatment without magnetic pulses. They also enrolled people who were not depressed to compare the data. Within a week of SNT treatment, the depressed patients experienced regular signal flow activity in the brain regions. As a result, patients reported that their depression symptoms had improved slightly. Previously, all patients chosen for this study had failed to respond to standard depression treatment.

The team believes that those suffering from the most severe forms of depression are likely to benefit the most from the treatment. "When we get a person with severe depression, we can look for this biomarker to decide how likely they are to respond well to SNT treatment," Mitra said. This study is an essential step toward understanding the biological mechanisms of Major Depressive Disorder, which is a leading cause of morbidity worldwide.The results have been reported in the journalMajor depressive disorder is widely hypothesized to result from disordered communication across brain-wide networks. Yet, prior resting-state-functional MRI studies of MDD have studied zero-lag temporal synchrony in brain activity absent directional information.

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