Sputum markers may predict remission in eosinophilic asthma. medtwitter asthma
Specific sputum markers, including higher sputum eosinophils, macrophages, and lymphocyte counts, were associated with remission after interleukin-5 –targeted therapy for patients with severe eosinophilic asthma. The finding was based on data from 52 individuals.
Although IL-5 therapies have been shown to be effective for improving asthma, patients' responses vary, write Catherine Moermans, PhD, of Liege University, Belgium, and colleagues. Biotherapies targeting IL-5 allow a tangible improvement of asthma. However, all patients do not respond the same way to these treatments, and reliable biomarkers for predicting treatment response are lacking, they say.the researchers recruited 52 adults with severe asthma who began anti-IL-5 treatment at a single center. The primary outcome was remission of asthma.
Remission was defined as meting all of the following criteria 1 year after therapy: no chronic treatment with oral corticosteroids; no exacerbation; asthma control questionnaire scores lower than 1.
At follow-up, 11 patients met the criteria for remission. These patients had significantly higher sputum eosinophil counts, sputum macrophage counts, and lymphocyte counts at baseline compared to those not in remission (
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