Results from a new study in mice suggest treatment for the age-related decline in fertility is “not a pipe dream.”
Would-be parents hoping to get pregnant face a ticking clock: The older potential mothers get, the more their fertility drops. A new study in mice may help explain why. Ovaries accumulate “stiff” tissue as they age, and researchers have found that reducing the amount of this tissue—“softening” the ovaries, as it were—restored fertility in the animals, raising the possibility that the same approach could work in humans.
Takashi Umehara, then a postdoc at the University of Adelaide, and colleagues wanted to determine whether ovarian fibrosis was responsible for falling fertility. Although female mice don’t undergo menopause, their ability to reproduce wanes as they get older. Despite these successes, the researchers weren’t sure whether reduced fibrosis drove the improved fertility, Robker says. “We didn’t know if [fibrosis] would be reversible,” she says, because it involves the accumulation of tough collagen strands. But when the scientists scrutinized the animals’ ovaries under the microscope, they found the amount of fibrosis was much lower in both groups of mice that received the drug than in the controls.
The team also tested two other molecules that bolster mitochondria—metformin, an antidiabetes drug sometimes prescribed for infertility, and MitoQ, which is often touted as an antiaging supplement. Both molecules lessened ovarian fibrosis in old mice but did not stimulate ovulation.
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