Is there sufficient evidence to support the use of Dexmedetomidine as an effective sleep aid for patients in the ICU?
Do we have enough data to recommend preemptive dexmedetomidine to improve sleep and reduce delirium in patients who don't require continuous sedation? Hard to say. The existing data were. Awash in heterogeneity, bias, and every other statistical limitation imaginable, this study found little to support dexmedetomidine. I suppose I could get on board with a brief, 40-minute infusion for patients otherwise at high risk for delirium or sleep disruption, given cost and side effects.
Aaron B. Holley, MD, is a professor of medicine at Uniformed Services University in Bethesda, Maryland, and a pulmonary/sleep and critical care medicine physician at MedStar Washington Hospital Center in Washington, DC. He covers a
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