Shortage of life-saving drug leaves immune-deficient patients in 'terrifying' spot: 'no replacement'

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Shortage of life-saving drug leaves immune-deficient patients in 'terrifying' spot: 'no replacement'
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A little-known drug shortage, of immune globulin (IG) poses a threat to thousands with immune deficiencies. One mom explains how it could impact her sons' lives.

After enduring extensive fertilization treatment and several difficult pregnancies, including a miscarriage and a stillbirth, Illinois law professor Sonia Green eventually grew the family she had so yearned for.

“Immune globulin provides antibody replacements,” John Boyle, president of the Immune Deficiency Foundation, explains to Yahoo Lifestyle. “If it were not for immune globulin, any pathogen — even the slightest cold — could be fatal or problematic.” The U.S. manufactures nearly 70 percent of the world’s IG products, according to Boyle, and has been unable to keep up with the worldwide demands for IG products as the medicine is now used for a growing variety of off-label treatments — something that has contributed to a 66 percent increase in its distribution from 2012 to 2018 across North America and Europe. While the U.S.

“This is not a classic drug shortage. If anything goes wrong with one plant, there’s a massive ripple effect, because it’s a very fragile supply chain,” Boyle explains. “If you don't have this therapy, as far as antibody deficiencies go, there is no replacement — there is no pill, there is no other therapy. We need antibodies and there's just nothing around it.”

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