Patients with heart failure with preserved ejection fraction and obesity lost weight and felt better while taking semaglutide vs placebo, but was the bar for success set too low in STEP-HFpEF?
. You could feel the excitement in the packed auditorium. The trial discussant was ebullient in his praise.
The study of glucagon-like peptide 1 receptor agonists as therapeutic agents in any chronic condition associated with obesity creates challenges for medical scientists.chronic condition. And this drug class consistently induces serious weight loss. One only needs to think about walking up a flight of stairs with and without a heavy backpack. In the matter of HFpEF, a condition that has dyspnea with exertion as one of its core symptoms, inducing weight loss will surely improve quality of life. If you breathe better, everything is better.As heart failure trials go, STEP-HFpEF enrolled a small sample size of just over 500 patients with well-documented HFpEF and obesity and randomly assigned them to semaglutide or placebo.
The choice of dual primary endpoint requires attention. This was a change from baseline in the Kansas City Cardiomyopathy Questionnaire clinical summary score and the change in body weight. Secondary endpoints included changes in 6-minute walk distance, a hierarchical composite of many endpoints , and changes in biomarkers.
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Wegovy Scores HFpEF Benefits in People With ObesityIn STEP-HFpEF, a prospective, randomized study of adults with HFpEF and obesity, weekly semaglutide weight-loss injections for 1 year led to substantial improvements in physical function and symptoms.
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