Researchers are utilizing the gene-editing technology CRISPR to modify the viruses that have evolved to engineer bacteria. CRISPR, the revolutionary gene-editing tool, is making waves in the scientific community once more with its potential to edit the genomes of viruses that infect bacteria. Le
CRISPR is a revolutionary gene editing technology that allows scientists to make precise changes to the DNA of living organisms. Scientists are now using it to engineer the viruses that evolved to engineer bacteria.
Led by CRISPR pioneers Jennifer Doudna and Jill Banfield, a team has used a rare form of CRISPR to engineer custom bacteriophages, a development that could aid in the treatment of drug-resistant infections and allow researchers to control microbiomes without the use of antibiotics. The research, published in, represents a significant achievement as the engineering of bacteriophages has long been a challenge for the scientific community.
CRISPR-Cas is a type of immune defense mechanism that many bacteria and archaea use against phages. A CRISPR-Cas system consists of short snippets ofthat are complementary to sequences in phage genes, allowing the microbe to recognize when invasive genetic material has been inserted, and scissor-like enzymes that neutralize the phage genes by cutting them into harmless pieces, after being guided into place by the RNA.
Project leaders Doudna and Banfield have developed numerous CRISPR-based tools together since they first collaborated on an early investigation of CRISPR in 2008. That work – performed at– was cited by the Nobel Prize committee when Doudna and her other collaborator, Emmanuelle Charpentier, received the prize in 2020.
Next, the team demonstrated that the system can be used to edit phage genomes rather than just chop them up defensively.
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