Two scientists, one Nigerian and one American, created a cutting-edge surveillance network to catch the next emerging disease before it becomes a pandemic.
Long-time collaborators Pardis Sabeti of the Broad Institute and Christian Happi of the African Centre of Excellence for Genomics of Infectious Diseases in Nigeria, are developing an early-warning system that could flag an emerging pandemic .Long-time collaborators Pardis Sabeti of the Broad Institute and Christian Happi of the African Centre of Excellence for Genomics of Infectious Diseases in Nigeria, are developing an early-warning system that could flag an emerging pandemic .
The pair met while studying malaria 25 years ago and grew close while working together on a lassa fever project in Sierra Leone. Then came late 2013, when people began falling ill in Guinea in West Africa. It would start with a fever and could end with death, but it still took months before health authorities were sufficiently concerned to investigate and take blood samples. Even once they did, the tests were ploddingly slow.
Sabeti and Happi considered an inspiring possibility: What if the active monitoring of viruses could happen on the ground in Africa by Africans? "I knew I was going to be dealing with something very dangerous," says Happi."And I remember telling my wife, 'If I make it back, fine. If I don't make it back, take care of the children.' And she told me, 'You've always said that you better die and save millions of people than to just let this thing spread. Go, God is gonna be with you.'"
This is ACEGID's war plan for thwarting disease in the region, an early warning protocol they're calling Sentinel. Say someone shows up at a clinic or hospital with a fever. "With the spread of pathogens," says Sabeti,"what's happening in one village is going to directly, quickly impact another."
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