A new study sheds light on the organization of proteins within mitochondria. Mitochondria, the 'powerhouses' of cells, play a crucial role in the energy production of organisms and are involved in various metabolic and signaling processes. Researchers from the University Hospital Bonn and the Unive
Mitochondria are small, dynamic organelles found in the cells of most eukaryotic organisms. They are often referred to as the “powerhouses of the cell” because they generate the majority of a cell’s supply of adenosine triphosphate , which is used as a source of chemical energy.Mitochondria, the “powerhouses” of cells, play a crucial role in the energy production of organisms and are involved in various metabolic and signaling processes.
Model of the quality control mechanism for removing arrested proteins from the mitochondrial entry gate. Credit: SchulteDefects in mitochondria lead to numerous diseases, especially of the nervous system. Therefore, the molecular understanding of mitochondrial processes is of the highest relevance for basic medical research. The molecular workers in the cell are usually proteins.
MitCOM reveals the organization into protein complexes of more than 90 percent of the mitochondrial proteins from baker’s yeast. This allows to the identification of new protein-protein interactions and protein complexes – important information for further studies.Researchers at UKB in cooperation with Collaborative Research Center 1218 “Regulation of cellular function by mitochondria,” have shown how this dataset can be used to elucidate new processes.
Research by Ph.D. student Arushi Gupta further revealed a pathway by which these tagged proteins are subsequently targeted for degradation. Understanding these processes is important because defects in protein import can lead to cellular damage and neurological diseases.
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