Sponsored: UTHealthSA scientists using a therapy on obese mice noted reduced appetite, more energy & weight loss in the rodents. Read how restraining an enzyme could possibly help us trim down, reduce appetite & fight obesity and diabetes. UTHealthSA
“We have an enzyme inhibitor that we want to make more specific to increase its effects,” said first author Sakie Katsumura, DDS, PhD, postdoctoral fellow in the Morita laboratory.The liver enzyme, called CNOT6L deadenylase, turns off messenger ribonucleic acids that ordinarily carry genetic instructions from the nucleus to sites in the cell where two liver proteins are made.
One of the proteins, growth differentiation factor 15 , sends signals to two regions of the hindbrain to control food intake. The other, fibroblast growth factor 21 , sends signals to brown and white adipose tissues to increase energy expenditure. CNOT6L deadenylase impedes mRNA code-carrying for both GDF15 and FGF21, which reduces these benefits.
, professor of medicine at UT Health San Antonio and director of the Sam and Ann Barshop Institute. “It is a new platform for thinking about how to treat this group of diseases.” According to the U.S. Centers for Disease Control and Prevention , more than 37 million Americans have diabetes. Type 2 diabetes represents at least 90% of the cases. In Texas, approximately 2.7 million people have diagnosed diabetes, and an additional 600,000 people in Texas have diabetes but don’t know it. Another 7 million people in Texas have prediabetes.
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