Artemisia annua has been revered in traditional Chinese medicine for over 2,000 years, particularly for producing artemisinin.
Sponsel indicates that natural products are invaluable to medical research, with roughly half of all prescription medications originating from them. He also notes that due to the complexity of cancer, it is improbable that a universal treatment will be developed. Therefore, the ongoing investigation into a variety of medicinal substances from various plants remains important.
Francis K. Yoshimoto, a UTSA assistant professor in chemistry, explains the extraction process: "We utilized methanol as the solvent. This crucial step led us to hypothesize how the compound interacts within biological systems." The researchers believe that Arteannuin B may inhibit cysteine proteases—protein-degrading enzymes—that are overexpressed in cancer cells. "We discovered that when we chemically reduced Arteannuin B, its effectiveness against GBM decreased significantly. This provided critical insights into its bioactive properties," adds Yoshimoto.
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