Researchers create synthetic scaffold to help grow lab muscletissue kingscollegelon advmater
The ECM acts as a connective scaffold that helps form the structure of myofibers. Having the ECM scaffold in the environment is vital for the growth and maturation of muscle tissue. Without a reliable way of replicating the ECM, scientists are unable to grow muscle tissues.
The new research explores the development of a synthetic, flexible scaffold which replicates the ECM. Electrospinning technology weaves elastic nanofibers from synthetic biomaterials to build an ECM-replicant scaffold that can be used to grow muscle tissue fromScanning electron microscopy images of the nanofiber scaffolds , and muscle cells , grown on the nanofiber scaffolds .
The paper shows that the synthetic-ECM—the nanofiber scaffold—successfully supported the normal growth and stabilization ofThe authors also inserted a molecular light sensor into the genome of the stem cells to create myofibers that contracted upon exposure to light pulses. This means artificial muscle tissue can be contracted like muscles in the body.
As a result, scientists can create many identical muscle tissue models for experiments. These help researchers to better understand contraction in muscle diseases, as well as testing drug candidates with the same ideal muscle tissue model. As well as modeling and testing drug candidates for muscle diseases, the artificial ECM scaffold has the potential to be used to grow replacement muscle tissue for patients with skeletal muscle injuries.
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