Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa

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Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa
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Nature research paper: Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa

and is provided in this format here as a response to the exceptional public-health crisis. This accepted manuscript will continue through the processes of copy editing and formatting to publication of a finalized version of record on nature.com. Please note there may be errors present in this version, which may affect the content, and all legal disclaimers apply.

The severe acute respiratory syndrome coronavirus 2 epidemic in southern Africa has been characterised by three distinct waves. The first was associated with a mix of SARS-CoV-2 lineages, whilst the second and third waves were driven by the Beta and Delta variants, respectively. In November 2021, genomic surveillance teams in South Africa and Botswana detected a new SARS-CoV-2 variant associated with a rapid resurgence of infections in Gauteng Province, South Africa.

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