Scientists in Alabama at hudsonalpha have identified a gene they say could be used to reverse pancreatic cancer’s resistance to chemotherapy, an advance that would bring a powerful weapon to the fight against one of cancer’s deadliest forms.
Scientists in Alabama have identified a gene they say could be used to reverse pancreatic cancer’s resistance to chemotherapy, an advance that would bring a powerful weapon to the fight against one of cancer’s deadliest forms.
HudsonAlpha Faculty Investigator Dr. Sara Cooper and her lab focus “on identifying novel targets to prevent cancer chemoresistance” in pancreatic cancer. The lab recently published results in the journalCooper and her HudsonAlpha colleagues had already linked the high presence of the gene ANGPTL4 The researchers used CRISPR, a tool that lets scientists “edit” gene pairs to slow the reproduction of the DNA segments linked to the cancer. “It also reduced ability of the cancer cells to migrate elsewhere,” HudsonAlpha said in a press release.
The data supports using the gene as potential drug targets. That could “aid in developing much-needed treatments for pancreatic cancer,” Cooper said.
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