Nature research paper: Profiling the human intestinal environment under physiological conditions
; we found that PhenylCA, LeuCA and TyroCA were not among the bile acids that decreased from device type 1 to 4. Together, these observations indicate that some microbially conjugated bile acids may be deconjugated by microorganisms while others are not. Previous studies did not detect these opposing longitudinal trends in microbially conjugated bile acids
In this study, participants concurrently ingested sets of four devices, each with distinct coatings to target the proximal to medial regions of the small intestine and more distal regions . After sampling, the devices were passed in the stool into specimen-collection containers and immediately frozen. After completion of sampling, the stool was thawed and the devices were retrieved by study staff.
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