The untapped potential of RNA structures univgroningen
) and, consequently, is not restricted to the analysis of co-transcriptional structure changes. Therefore, in Mthe structures of a large pool of randomly generated single-nucleotide sequence variants of an RNA of interest are queried by chemical probing and changes in the reactivity pattern across mutants indirectly inform on the presence of an alternative RNA conformationapproach is that it cannot be scaled up to analyse the entire transcriptome.
, Mutate and map provides an indirect way to deconvolve RNA structure ensembles by randomly generating a large number of single-nucleotide substitution mutants of an RNA of interest, followed by structure probing analysis. Mutations capable of disrupting base-pairing interactions in the wild-type structure, whilst stabilizing alternative folds, will cause a redistribution of the relative abundance of the structures within the ensemble, leading to reactivity changes.
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