Proteomic analysis of 28 tissue types across 40 cancer types reveals new biomarkers of cancer vulnerabilities. NBThighlight
There are 8,498 proteins with evidence of cell types and broad post-transcriptional regulationRandom downsampling reveals highly connected and co-regulated protein networksThe proteome provides unique insights into disease biology beyond the genome and transcriptome. A lack of large proteomic datasets has restricted the identification of new cancer biomarkers. Here, proteomes of 949 cancer cell lines across 28 tissue types are analyzed by mass spectrometry.
Deploying a workflow to quantify 8,498 proteins, these data capture evidence of cell-type and post-transcriptional modifications. Integrating multi-omics, drug response, and CRISPR-Cas9 gene essentiality screens with a deep learning-based pipeline reveals thousands of protein biomarkers of cancer vulnerabilities that are not significant at the transcript level. The power of the proteome to predict drug response is very similar to that of the transcriptome.
Indonesia Berita Terbaru, Indonesia Berita utama
Similar News:Anda juga dapat membaca berita serupa dengan ini yang kami kumpulkan dari sumber berita lain.
New miracle drug may increase the human lifespan to 200 yearsA new type of miracle drug could let scientists increase the human lifespan to 200 years and beyond by killing off unneeded cells.
Baca lebih lajut »
High-Flying Experiment: Do Stem Cells Grow Better in Space?Researcher Dhruv Sareen’s own stem cells are now orbiting the Earth. The mission? To test whether they’ll grow better in zero gravity.
Baca lebih lajut »
Millions Of Women Skipped Cancer Screenings Because Of Covid Pandemic, Study SuggestsThe Covid-19 pandemic caused millions of women—especially Hispanic women and those with lower incomes—to forgo breast and cervical cancer screenings in 2020, according to researchers.
Baca lebih lajut »
Cancer prevention, treatment and survivorship seminar Aug. 20Mission Hope Cancer Center will host a special cancer prevention, treatment and survivorship seminar on Saturday, Aug. 20 that will offer practical guidance for staying well, improving quality of life
Baca lebih lajut »
Millions Of Women Skipped Cancer Screenings Because Of Covid Pandemic, Study SuggestsThe Covid-19 pandemic caused millions of women—especially Hispanic women and those with lower incomes—to forgo breast and cervical cancer screenings in 2020, according to researchers.
Baca lebih lajut »
No, Humans Didn't Evolve From the Ancestors of Living ApesA new study shows that the last ancestor before the lineages of apes and humans diverged likely didn't share traits of either humans or apes, and it has yet to be found.
Baca lebih lajut »